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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEK
All Species:
31.82
Human Site:
T114
Identified Species:
70
UniProt:
P08567
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08567
NP_002655.2
350
40097
T114
Q
K
F
A
R
K
S
T
R
R
S
I
R
L
P
Chimpanzee
Pan troglodytes
XP_515524
350
40124
T114
Q
K
F
A
R
K
S
T
R
R
S
I
R
L
P
Rhesus Macaque
Macaca mulatta
XP_001094492
350
40060
T114
Q
K
F
A
R
K
S
T
R
R
S
I
R
L
P
Dog
Lupus familis
XP_537486
375
42096
L139
K
V
Q
Q
L
H
V
L
R
N
S
F
K
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHK5
350
39882
T114
Q
K
F
A
R
K
S
T
R
R
S
I
R
L
P
Rat
Rattus norvegicus
Q4KM33
350
39977
T114
Q
K
F
A
R
K
S
T
R
R
S
I
R
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512767
334
37917
T98
Q
R
F
A
R
K
S
T
R
R
S
I
R
L
P
Chicken
Gallus gallus
NP_990194
353
40280
T116
Q
R
F
A
R
K
S
T
R
K
S
I
R
L
P
Frog
Xenopus laevis
NP_001080021
289
33430
W93
H
Q
E
E
R
D
A
W
V
K
D
L
K
K
A
Zebra Danio
Brachydanio rerio
NP_957135
352
40176
T114
K
K
F
A
R
K
S
T
R
R
S
I
R
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781827
375
42698
E112
E
C
D
R
S
K
E
E
V
H
P
T
S
P
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
36
N.A.
92
92
N.A.
80.5
81.5
63.1
67.3
N.A.
N.A.
N.A.
N.A.
34.4
Protein Similarity:
100
100
100
55.7
N.A.
96.8
97.1
N.A.
89.4
90.6
73.7
83.8
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Identity:
100
100
100
26.6
N.A.
100
100
N.A.
93.3
86.6
6.6
93.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
40
N.A.
100
100
N.A.
100
100
40
100
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
73
0
0
10
0
0
0
0
0
0
0
10
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
10
0
0
0
0
10
0
0
0
0
% D
% Glu:
10
0
10
10
0
0
10
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
73
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
10
0
0
0
0
10
0
0
0
10
0
0
0
0
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
73
0
0
0
% I
% Lys:
19
55
0
0
0
82
0
0
0
19
0
0
19
10
0
% K
% Leu:
0
0
0
0
10
0
0
10
0
0
0
10
0
82
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
82
% P
% Gln:
64
10
10
10
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
19
0
10
82
0
0
0
82
64
0
0
73
0
0
% R
% Ser:
0
0
0
0
10
0
73
0
0
0
82
0
10
0
0
% S
% Thr:
0
0
0
0
0
0
0
73
0
0
0
10
0
0
0
% T
% Val:
0
10
0
0
0
0
10
0
19
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _